C&S GMS wish to implement an AI-assisted automated karyotyping solution across all sites, with capability to also deliver automated FISH analysis. The requirements documented are vendor agnostic and have been developed to inform the selection and implementation of a karyotyping / FISH solution. Requirements C&S GMS have prepared a supporting document to demonstrate the requirements of the karyotyping solution, but in summary the system must: • Deliver automated slide scanning, automated cell selection and capture, and AI-assisted digital karyotyping capability across our laboratories, • Enable integration with existing systems where possible – details of existing systems are in Appendix 1. • Security and Compliance: Meet all relevant data security and privacy regulations. • Allow for centralisation of “wet laboratory” work at 2 sites and distribution of images, allowing distributed analysis and reporting at all 3 sites plus remote working from home. • FISH capability is also required, meeting specified performance expectations for both cell suspensions and FFPE slides including tissue-matching function, and ideally automated scanning. • Data storage and retention capability